Lecture Notes 1
Notes on some selected topics for B.Sc. and M.Sc. Chemistry students of M.G.University and other Universities in Kerala.
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Professor E.J.Corey of
Protecting groups are very important in organic synthesis. There are many occasions when a reagent, like an oxidizing or a reducing agent, may attack several possible locations in a molecule, but we may want the reaction to take place only at one of them. Protecting groups are used to block other functional groups temporarily from reacting, so that reaction may take place only at the desired location in the molecule. This note is an introduction to CBZ, BOC, FMOC, trityl, benzyl, tetrahydropyranyl, trialkylsilyl, t-butyl, acetal and thioacetal groups frequently used to protect amino, hydroxyl, thiol, carboxyl and carbonyl groups.This note is an introduction to special selective reactions like enol alkylation, Stork enamine alkylation and acylation, Mitsunobu reaction, 1,3-dipolar cycloadditions, umpolungs, electrochemical reduction and oxidation reactions, Prevost and Woodward hydroxylation reactions, de-oxygenation of epoxides to alkenes and olefin metathesis.
These are reactions in which the concentrations of two species increase and decrease alternately for a long time before equilibrium is reached. It is hypothesised that many periodically varying biological phenomena such as breathing and heart beat may be controlled by oscillating chemical reactions. The notes provide a rudimentary introduction to the mechanism of such reactions. Watch an oscillating reaction!
Reaction dynamics in molecular beams. Rates of reactions, Hard sphere collision theory, glory scattering, rainbow scattering, collision cross section, reaction cross section, impact parameter, collision density, corrections for energy and orientation, pre-exponential factor, steric factor, calculations.